Identification of Ube2b as a Novel Target of Androgen Receptor in Mouse Sertoli Cells1
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چکیده
منابع مشابه
AB46. Screening and identification for the target genes of androgen receptor in mouse Sertoli cells
Androgen and androgen receptor (AR) play important roles in spermatogenesis, yet detailed androgen/ AR signals in Sertoli cells remain unclear. To identify AR target genes in Sertoli cells, we analyzed the gene expression profiles of testis between mice lacking AR in Sertoli cells (SAR) and their littermate wild-type (WT) mice. Digital gene expression analysis identified 2,276 genes downregulat...
متن کاملIdentification of testosterone-/androgen receptor-regulated genes in mouse Sertoli cells.
Androgen and androgen receptor (AR) play important roles in male spermatogenesis and fertility, yet detailed androgen/AR signals in Sertoli cells remain unclear. To identify AR target genes in Sertoli cells, we analyzed the gene expression profiles of testis between mice lacking AR in Sertoli cells (S-AR(-/y)) and their littermate wild-type (WT) mice. Digital gene expression analysis identified...
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Although decades of research have established that androgen is essential for spermatogenesis, androgen's mechanism of action remains elusive. This is in part because only a few androgen-responsive genes have been definitively identified in the testis. Here, we propose that microRNAs--small, non-coding RNAs--are one class of androgen-regulated trans-acting factors in the testis. Specifically, by...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2013
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.112.103648